Drugs have always been a theme in the Fallout game series. They are mostly chemical nature. They have useful effects on the character and often help to improve the performance or endurance, or just have a healing effect. In Fallout 4, the selection has been increased so there are now 33 different types of drugs. All have a different effect and some Chems can be addictive. What Chems are there, what impact they have and how you can cure the addiction, we have summarized all the useful information in a guide below

Some of the Chems can be found right at the beginning of the game. They can be hidden anywhere. Search for the drug especially in coolers or in the remains of your enemies. You may be able to use to improve your skills for a certain time to heal or to simply sell.
What types of drugs are there, what these Chems cause and what they are worth, you can see in the following list.

Drug: Addictol - Effect: Heals all dependencies – Crafting: impossible - Dependence: no - value: 125
Drug: Berry Mentats - Effect: emphasizes all living MDG's – Crafting: possible - Dependency: 10% - Value: 60
Drug: Buffjet - Effect: Slows down the time, strength +3 Stamina +3, Max HP +65, Max AP +35 - Crafting possible - Dependency: 15% - Value: 75
Drug: BUFFOUT - Effect: Strength +2, Stamina +2, Max HP +50 – Crafting: impossible - Dependency: 10% - Value: 45
Drug: Bufftats - Effect: Strength +3, +3 Stamina, Perception +3, Max HP +65 – Crafting: possible - Dependency: 15% - Value: 75
Drug: Calmex - Effect: x2 surreptitious attacks, Perception +3, +3 movement – Crafting: impossible - Dependency: 15% - Value: 100
Drug: Curie's Healthpak - Effect: HP +35, wheel -300 – Crafting: impossible - Dependency: none - value: 90
Drug: Daddy-O - Effect: Intellect +3, +3 Perception, Charisma -2 – Crafting: impossible - dependency: 15% - Value: 50
Drug: Day Tripper - Effect: happiness +3, +3 Charisma, -2 Strength – Crafting: impossible - Dependency: 15% - Value: 40
Drug: Refreshing Cold Drink - Effect: Heals all dependencies, HP +500, wheel yes-1000 – Crafting: possible - Depending: no - value: 110
Drug: Fury - Effect: Increases damage of melee weapons by 50% - Crafting: possible - Dependency: 15% - Value: 70
Drug: Glowing Blood pack - Effect: HP +40%, Wheel Resist +75 – Crafting: possible - Depending: no - value: 30
Drug: Grape Mentats - Effect: for 10% of customers buy less, sell for 10% more, Charisma +5 - Crafting possible - Dependency: 10% - Value: 60
Drug: Blood Pack - Effect: HP +50, +20 wheel – Crafting: impossible - Dependency: 10% - Value: 50
Drug: Jet - Effect: slowing the time – Crafting: possible - Dependency: 10% - Value: 50
Drug: Jet Fuel - Effect: increases the AP-charging rate – Crafting: possible - Dependency: 15% - Value: 60
Drug: Med-X - Effect: Damage Resistance +25 – Crafting: impossible - Dependency: 10% - Value: 50
Drug: Mentats - Effect: +2 Intelligence, +2 Perception – Crafting: impossible - Dependency: 10% - Value: 50
Drug: Mysterious serum - Effect: Damage Resistance +50, wheel +35,000 - Crafting: impossible - Dependency: none - value: 25
Drug: Oranges Mentats - Effect: +10% accuracy in VATS – Crafting: possible - Dependency: 10% - Value: 60
Drug: Overdrive - Effect: +25% critical strike chance, damage +25% - Crafting: possible - Dependency: 15% - Value: 55
Drug: Psycho - Effect: Damage + 25%, + 25% damage resistance – Crafting: possible - Dependency: 10% - Value: 50
Drug: Psychobuff - Effect: Damage +25%, +3 Strength, Stamina +3, Max HP +65, Crafting: possible - Dependency: 15% - Value: 70
Drug: Psycho Jet - Effect: slowing the time for 15 seconds, damage +25%, Damage Resistance +35, Max AP +35 – Crafting: possible -Dependency: 15% - Value: 70
Drug: Psychotats - Effect: Damage + 25%, Damage Resistance +15, Perception +3 – Crafting: impossible - Dependency: 15% - Value: 70
Drug: RadAway - Effect: wheel -300 - Crafting possible - Depending: no - value: 80
Drug: Rad-X - Effect: Radiation Resistance +100 - Crafting impossible - Depending: no - value: 40
Drug: Skeeto Spit - Effect: Max HP +25 – Crafting: possible - Depending: no - value: 40
Drug: Stimpak - Effect: HP +30% - Crafting: possible - Depending: no - value: 48
Drug: Ultra Jet - Effect: slowing the time for 15 seconds, Max AP +100 - Crafting possible - Dependency: 15% - Value: 67
Drug: Vault 81 Cure - Effect: HP + 50% - Crafting: impossible - Dependence: no - value: 400
Drug: X-111 - Effect: wheel -600 - Crafting impossible - Dependence: no - value: 40
Drug: X-Cell - Effect: wheel strength +2, +2 Perception, Endurance +2, +2 Charisma, Intelligence +2, +2 Agility, Luck +2 – Crafting: impossible - Dependency: 35% - Value: 60

You can craft your own drugs at a laboratory station. Some you can find easily others you get as part of a quest. Look around everywhere: In Vaults, settlements or with your companion Curie.

Cure Drug Addiction

Have you found favor from the effects of individual drugs, it may happen that you will depend on this. There are three different ways to cure drug addiction:

- Expand capacity in the skill tree (Perk "drug resistance")
- Dependence heal with drugs
- Healing by doctor

Once you have reached level 22, you can unlock the perk "drug resistance". For this one you need Stamina 4. This effect reduces the chance of becoming dependent on Chems by half.


Do you still want to invest your hard-earning skill points in other skills, then you can still heal your addiction. Use this drug, because there are special Chems that free you from the drug addiction. And finally you can see Dr. Ron in Diamond City and let him heal at your dependence. For this, you have to pay him 75 Caps.

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